The Q705K and F359L Single-Nucleotide Polymorphisms of NOD-Like Receptor Signaling Pathway: Association with Chronic Pancreatitis, Pancreatic Cancer, and Periodontitis
Identifieur interne : 000C53 ( Main/Exploration ); précédent : 000C52; suivant : 000C54The Q705K and F359L Single-Nucleotide Polymorphisms of NOD-Like Receptor Signaling Pathway: Association with Chronic Pancreatitis, Pancreatic Cancer, and Periodontitis
Auteurs : Andrzej Miskiewicz [Pologne] ; Grzegorz Szparecki [Pologne] ; Marek Durlik [Pologne] ; Gra Yna Rydzewska [Pologne] ; Ireneusz Ziobrowski [Pologne] ; Renata G Rska [Pologne]Source :
- Archivum Immunologiae et Therapiae Experimentalis [ 0004-069X ] ; 2015.
Abstract
The aim of this study was to establish the correlation between the occurrence of Q705K and F359L polymorphisms in patients diagnosed with pancreatic diseases and periodontal conditions of various degrees of severity. The above-mentioned genetic markers were assessed in patients with pancreatic cancer (
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DOI: 10.1007/s00005-015-0355-9
PubMed: 26253076
PubMed Central: 4633443
Affiliations:
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Medical Univeristy of Warsaw, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathology, Medical Univeristy of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Durlik, Marek" sort="Durlik, Marek" uniqKey="Durlik M" first="Marek" last="Durlik">Marek Durlik</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Gastroenterological and Transplant Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Gastroenterological and Transplant Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Rydzewska, Gra Yna" sort="Rydzewska, Gra Yna" uniqKey="Rydzewska G" first="Gra Yna" last="Rydzewska">Gra Yna Rydzewska</name><affiliation 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sortKey="G Rska, Renata" sort="G Rska, Renata" uniqKey="G Rska R" first="Renata" last="G Rska">Renata G Rska</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Periodontology, Medical University of Warsaw, Miodowa 18, 00-246 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Periodontology, Medical University of Warsaw, Miodowa 18, 00-246 Warsaw</wicri:regionArea><wicri:noRegion>00-246 Warsaw</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26253076</idno><idno type="pmc">4633443</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633443</idno><idno type="RBID">PMC:4633443</idno><idno type="doi">10.1007/s00005-015-0355-9</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000B61</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B61</idno><idno 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A" first="Andrzej" last="Miskiewicz">Andrzej Miskiewicz</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Periodontology, Medical University of Warsaw, Miodowa 18, 00-246 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Periodontology, Medical University of Warsaw, Miodowa 18, 00-246 Warsaw</wicri:regionArea><wicri:noRegion>00-246 Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Szparecki, Grzegorz" sort="Szparecki, Grzegorz" uniqKey="Szparecki G" first="Grzegorz" last="Szparecki">Grzegorz Szparecki</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pathology, Medical Univeristy of Warsaw, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Pathology, Medical Univeristy of Warsaw, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Durlik, Marek" sort="Durlik, Marek" uniqKey="Durlik M" first="Marek" last="Durlik">Marek Durlik</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Gastroenterological and Transplant Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Gastroenterological and Transplant Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Rydzewska, Gra Yna" sort="Rydzewska, Gra Yna" uniqKey="Rydzewska G" first="Gra Yna" last="Rydzewska">Gra Yna Rydzewska</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Department of Gastroenterology, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Gastroenterology, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Ziobrowski, Ireneusz" sort="Ziobrowski, Ireneusz" uniqKey="Ziobrowski I" first="Ireneusz" last="Ziobrowski">Ireneusz Ziobrowski</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Gastroenterological and Transplant Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Gastroenterological and Transplant Surgery, Central Clinical Hospital, Ministry of Internal Affairs, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="G Rska, Renata" sort="G Rska, Renata" uniqKey="G Rska R" first="Renata" last="G Rska">Renata G Rska</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Periodontology, Medical University of Warsaw, Miodowa 18, 00-246 Warsaw, Poland</nlm:aff><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Periodontology, Medical University of Warsaw, Miodowa 18, 00-246 Warsaw</wicri:regionArea><wicri:noRegion>00-246 Warsaw</wicri:noRegion></affiliation></author></analytic><series><title level="j">Archivum Immunologiae et Therapiae Experimentalis</title><idno type="ISSN">0004-069X</idno><idno type="eISSN">1661-4917</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The aim of this study was to establish the correlation between the occurrence of Q705K and F359L polymorphisms in patients diagnosed with pancreatic diseases and periodontal conditions of various degrees of severity. The above-mentioned genetic markers were assessed in patients with pancreatic cancer (<italic>n</italic> = 18) and chronic pancreatitis (<italic>n</italic> = 39) as well as in a healthy control group (<italic>n</italic> = 115). The established inclusion criteria were the following: Caucasian descent, non-smoking, and age range 20–80, with different levels of periodontitis activity according to S. Offenbacher’s scale. The genotyping reactions were performed by means of an RT-PCR with the use of TaqMan<sup>®</sup> genotyping assay. Results of the study revealed that the state of periodontium was significantly worse in patients with chronic pancreatitis. The Q705K and F359L polymorphisms were associated with more advanced cases of periodontitis measured by clinical attachment level, whereas the Q705K was associated with intensified bleeding index. Furthermore, the F359L single-nucleotide polymorphism was significantly higher in the group with chronic pancreatitis (<italic>p</italic> < 0.0001; OR = 6.8571). Whereas, the prevalence of Q705K polymorphism was higher in the group of pancreatic cancer (<italic>p</italic> = 0.107; OR = 3.3939). This study suggests that the exaggerated inflammatory response provoked by Q705K and F359L might be the common denominator for periodontitis, pancreatic cancer, and chronic pancreatitis. These findings might constitute the basis for a new diagnostic and therapeutic approach.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Belibasakis, Gn" uniqKey="Belibasakis G">GN Belibasakis</name></author><author><name sortKey="Johansson, A" uniqKey="Johansson A">A Johansson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camen, Gc" uniqKey="Camen G">GC Camen</name></author><author><name sortKey="Caraivan, O" uniqKey="Caraivan O">O Caraivan</name></author><author><name sortKey="Olteanu, M" uniqKey="Olteanu M">M Olteanu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cummings, Jr" uniqKey="Cummings J">JR Cummings</name></author><author><name sortKey="Cooney, Rm" uniqKey="Cooney R">RM Cooney</name></author><author><name sortKey="Clarke, G" uniqKey="Clarke G">G Clarke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Las 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first="Andrzej" last="Miskiewicz">Andrzej Miskiewicz</name></noRegion><name sortKey="Durlik, Marek" sort="Durlik, Marek" uniqKey="Durlik M" first="Marek" last="Durlik">Marek Durlik</name><name sortKey="G Rska, Renata" sort="G Rska, Renata" uniqKey="G Rska R" first="Renata" last="G Rska">Renata G Rska</name><name sortKey="Rydzewska, Gra Yna" sort="Rydzewska, Gra Yna" uniqKey="Rydzewska G" first="Gra Yna" last="Rydzewska">Gra Yna Rydzewska</name><name sortKey="Szparecki, Grzegorz" sort="Szparecki, Grzegorz" uniqKey="Szparecki G" first="Grzegorz" last="Szparecki">Grzegorz Szparecki</name><name sortKey="Ziobrowski, Ireneusz" sort="Ziobrowski, Ireneusz" uniqKey="Ziobrowski I" first="Ireneusz" last="Ziobrowski">Ireneusz Ziobrowski</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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